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Latest Research Articles From JNNP


     

    • CSF ferritin predicts CSF A{beta} decline in biomarker-determined Alzheimers disease

      CSF ferritin relationship to CSF Aβ could be used to identify AD patients for iron chelation therapy This JNNP paper by an excellent team of investigators1 has built on many years of study that has shown loss of iron homeostasis in brain of persons with Alzheimer’s disease (AD). As the authors pointed out, iron has been identified with amyloid plaques and has been suggested to …

     

    • Iron{middle dot}ic facts about dementia

      ­ Background Alzheimer’s disease (AD) remains as a silent and increasing threat to public health. More than 200 clinical trials for AD have ended with disappointing results and basically empty-handed. The amyloid hypothesis as a primary culprit of AD still centralises most of the efforts in the academic and private sectors, but we need to start to explore alternative avenues for ear …

     

    • Meaning of psychiatric symptoms in frontotemporal dementia

      The meaning of psychiatric symptoms prior to a diagnosis of genetic frontotemporal dementia is discussed as either being part of a prodrome or being a sign of congenital neuronal vulnerability. Cheran et al1 in this journal investigated the nature of lifetime psychiatric symptoms in preclinical MAPT mutation carriers. Compared with their non-carrier relatives as well as the population, they more o …