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Latest Research Articles From JNNP


     

    • Correction: Platelet abnormalities in Huntingtons disease

      Denis HL, Lamontagne-Proulx J, St-Amour I, et al. Platelet abnormalities in Huntington’s disease. J Neurol Neurosurg Psychiatry 2019;90:272–83. doi: 10.1136/jnnp-2018-318854. In this published article, the author Hassan El Hajj should have been the 7th author. Dr El Hajj is affiliated with; 1 Centre de Recherche du CHU de Québec, Québec, QC, Canada 6 Département de …

     

    • Split elbow sign: more evidence for the importance of cortical dysfunction in ALS

      Dissociated muscle atrophy (DMA) is a well-recognised clinical phenomenon in amyotrophic lateral sclerosis (ALS).1 2 The best recognised of these phenomena is the split hand sign, clinically characterised by preferential wasting and weakness of the thenar group of intrinsic hand muscles (abductor pollicis brevis and first dorsal interosseous) compared to the hypothenar group.1 3 4 In addition, a s …

     

    • Relative preservation of triceps over biceps strength in upper limb-onset ALS: the 'split elbow

      Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor system. The split hand sign in ALS refers to observed preferential weakness of the lateral hand muscles, which is unexplained. One possibility is larger cortical representation of the lateral hand compared with the medial. Biceps strength is usually preserved relative to triceps in neurological conditions, bu …

     

    • Validation of the revised classification of cognitive and behavioural impairment in ALS

      Objective In 2017, the diagnostic criteria for cognitive and behavioural impairment in amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (ALSFTD-1) have been modified (ALSFTD-2) with the inclusion of a novel category (ALS with combined cognitive and behavioural impairment, ALScbi) and with changes of operational criteria of the other categories (ALS with cognitive impairment (ALSci) …