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Latest Research Articles From JNNP


    • Lithium: a slow burner

      It took Mogens Schou and his collaborators two decades to get lithium accepted for the prevention of mania. Along the way he was vilified and his scientific objectivity questioned. These regrettable delays led to many unnecessary suicides. More profitable rebranded anticonvulsants with less efficacy now threaten lithium’s primacy as the gold standard treatment for bipolar 1 disorder In 1949, …

     

    • Chitinases, neuroinflammation and biomarkers in ALS

      Neuro-inflammatory biomarkers in ALS imply glial pathology CSF chitinase (Chit-1) and phosphorylated neurofilament heavy chain levels are both raised in patients with amyotrophic lateral sclerosis (ALS), tweaking interest in these proteins as potential disease biomarkers,1 2 for example, in selecting patients for clinical trials. Here, Vu et al3 show that elevated CSF chitinase levels delineate a …

     

    • Targeting the centromedian thalamic nucleus for deep brain stimulation

      Objectives Deep brain stimulation (DBS) of the centromedian thalamic nucleus (CM) is an emerging treatment for multiple brain diseases, including the drug-resistant epilepsy Lennox-Gastaut syndrome (LGS). We aimed to improve neurosurgical targeting of the CM by: (1) developing a structural MRI approach for CM visualisation, (2) identifying the CM’s neurophysiological characteristics using mi …