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Latest Research Articles From JNNP


    • Retraction

      Sato Y, Asoh T, Metoki N, et al. Efficacy of methylprednisolone pulse therapy on neuroleptic malignant syndrome in Parkinson’s disease. J Neurol Neurosurg Psychiatry 2003;74:574–576. This article has been retracted. The editor received a letter from Dr Yoshihiro Sato retracting this article and two others also published in Journal of Neurology Neurosurgery and Psychiatry. Dr …

     

    • Emergence of neurophysiological biomarkers of Alzheimer disease

      Non-invasive brain stimulation techniques can reveal early synaptic dysfunction, characterise pathophysiological changes in cortical circuits and predict disease progression in Alzheimer disease Motta and coworkers ( in their JNNP paper1) used a non-invasive repetitive transcranial magnetic stimulation (TMS) protocol to evaluate brain plasticity in patients with Alzheimer disease (AD). More than 1 …

     

    • Vitamin D3 as a potentially modifiable factor in mild cognitive impairment

      More biomarker-based research is required to determine the effectiveness of interventions in subjects with mild cognitive impairment (MCI) MCI is a clinical diagnostic term for elderly subjects with impaired cognitive performance that does not significantly interfere with independent living. MCI, an intermediate condition between normal cognition and dementia, is typically divided into amnestic or …

     

    • Transcranial magnetic stimulation predicts cognitive decline in patients with Alzheimers disease

      Objective To determine the ability of transcranial magnetic stimulation (TMS) in detecting synaptic impairment in patients with Alzheimer’s disease (AD) and predicting cognitive decline since the early phases of the disease. Methods We used TMS-based parameters to evaluate long-term potentiation (LTP)-like cortical plasticity and cholinergic activity as measured by short afferent inhibi …