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Latest Research Articles From JNNP


    • Cognitive-behavioural therapy does meaningfully reduce depression in people with epilepsy

      "Why should we require better ‘number needed to treat’ statistics from psychological than from pharmacological treatments?" Reading the title of the study by Noble et al1 in Journal of Neurology, Neurosurgery and Psychiatry, ‘Cognitive-behavioural therapy does not meaningfully reduce depression in most people with epilepsy: a systematic review with a reliable …

     

    • Inflammatory neuropathies: all shapes and sizes

      One small step for precision medicine in inflammatory neuropathy Appreciation of the importance of nodal and paranodal regions in the pathophysiology of demyelinating autoimmune neuropathies has been a major recent milestone in the delineation of peripheral autoimmune disorders.1 In the JNNP paper by Doppler et al2, 140 patients with inflammatory neuropathy were screened for IgM antibodies ta …

     

     

    • Systematic review and network meta-analysis of resective surgery for mesial temporal lobe epilepsy

      Objective To evaluate the effectiveness of anterior temporal lobectomy (ATL) versus selective amygdalohippocampectomy (SAH) on seizure-free outcome in patients with temporal lobe epilepsy, using both direct and indirect evidence from the literature. Methods MEDLINE, Embase and Cochrane databases were searched for original research articles and systematic reviews comparing ATL versus SAH, and ATL o …

     

    • Neurofascin-155 IgM autoantibodies in patients with inflammatory neuropathies

      Objectives Recently, IgG autoantibodies against different paranodal proteins have been detected and this has led to important advances in the management of inflammatory neuropathies. In contrast, not much is known on IgM autoantibodies against paranodal proteins. Methods In the present study, we screened a large cohort of patients (n=140) with inflammatory neuropathies for IgM autoantibodies again …